Episode 389 – Robb & Nicki Q&A #3


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Hey Folks!

We’re back with another Q&A episode!

If you have a question for a future episode, especially questions for Tyler and Luis of KetoGains on the next Q&A, submit them here https://robbwolf.com/contact/submit-a-question-for-the-podcast/

Show Notes:

 

  1. (2:49) 23 and Me
    Kristin says:
    Robb and Nicki!
    Loved the first q&a back! I wanted to ask an expansion on the FTO gene Polymorphism question. I my self also ran my 23andme data through FoundMYFitness as a Rhonda Patrick follower and I have the similar FTO well several FTO genes came up but also the PPAR alpha gene came up that I know is a big part of ketosis. My question is can I attempt and Keto diet and Ketosis with using mainly PUFA and MUFA and still achieve ketosis with this polymorphism or am I better off to not focus on achieving ketosis?Thank you for all that you put in the world I just received you Wired to Eat book and started reading it! Love it so far!Kristin

NOTES:
FTO: https://academic.oup.com/jn/article/142/5/824/4630756
Fat Mass and Obesity–Associated Gene
Evolutionary Advantage-STRONG tendency toward obesity. Powerful adaptation in ancestral environment.

Evolutionary advantage not specific to Thrifty gene hypothesis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031802/pdf/yjbm_87_2_99.pdf

Susceptibility to obesity (and inflammation)
https://www.diva-portal.org/smash/get/diva2:406173/FULLTEXT01.pdf

Drivers towards energy efficiency…back side of this is constrained Energy Hypothesis:
https://journals.lww.com/acsm-essr/Fulltext/2015/07000/Constrained_Total_Energy_Expenditure_and_the.3.aspx

Game theory and energy balance: http://journals.sagepub.com/doi/full/10.1177/1550147717720792

PPAR Alpha: https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1528-1167.2008.01840.x

Peroxisome proliferator-activated receptor alpha is a drug/fatty acid-activated transcription factor involved in the starvation response,

Other SNP’s like CPT-1

 

  1. (16:45) Ketone IVs / Ketone Ringer
    Stijn says:
    Dear Robb,
    Dear Robb Wolf team,For years I’ve wondered about using ketone bodies in IVs at intensive care, in the same way that glucose solutions are used. I imagine there being less inflammation versus the glucose, and thus better recovery. Though the effect might be minimal in a non-keto-adapted person. Then I am skipping over the entire blue light issue from all the fluorescents at a hospital. I recently watched your talk at Paleo FX, “Ketogenic Diets for Traumatic Brain Injury Keeping the Baby with the Bathwater”. In brief you mention ketone ringers in an acute setting, traumatic brain injury and research in Japan. Why not use ketone bodies at intensive care, or even other settings? Have you seen research on this? Here’s how I thought about it: my dad was at the ICU after cardiac arrest, and I saw the glucose syringes. Then I thought about inflammation and ketones. And I remembered reading that heart muscle likes ketones. Maybe we can save more people with ketone IVs…Please share your thoughts. I’m also interested in the Japanese research on ketone ringers, if you can link that.Thank you very much.Be well,
    Stijn De Puydt

NOTES:
Ketone ringer solution-
https://iubmb.onlinelibrary.wiley.com/doi/pdf/10.1080/152165401753311780

MCT Keto diet: https://iubmb.onlinelibrary.wiley.com/doi/pdf/10.1080/152165401753311780

High glucose load negated benefits!!

 

  1. (20:54) Monkfruit

G says:
Hi. Can you briefly give me the straight dope on Monkfruit? I heard it doesn’t spike your blood glucose levels making it a good alternative to sugar. I’m also guessing it still triggers pleasure centers in your brain which can lead to craving sweets.
My girl wanted to know how does Monkfruit Maple Syrup differ from 100% Pure Maple Syrup?
Thank you for your time,
g

Notes: https://www.nature.com/articles/ijo2016225

Generally not a huge effect: https://www.nature.com/articles/ijo2016225

 

  1. (24:07) Alternatives to the classic Norcal Marg
    Colin says:
    Hey Rob, I like that you are back to doing some Q&A’s and Nicki did a good job being your cohost. Do miss the ever large and in charge Greg Everett’s humor though, “how does gravel burn,” classic. Anyways, what are your thoughts on a Bone Broth Bullshot in lieu of your Norcal Marg? Potential pro/cons? On a second note, what if you were to add some glycine to that Norcal M? Give just a little sweetness and I would think there are some potentially extra benefits to that addition.. After listening to Chris Masterjohn’s panel discussion on glycine, that crossed my mind.  Curious on your take. Thanks for everything you are doing (Paleo, health, keto, sustainability, controversial truths, etc.). While you are winding the clock back a little, you should get the Kraken on and let him destroy some questions.

 

  1. (27:44) Exercise induced Hypoglycemia
    Greg says:
    Robb, hoping to get your insight into a problem I am experiencing. Non-diagnosed Diabetic. 6’1″, 200 pounds, athletic build. Blood sugar drops into 60-69 mg/dL during moderate-intense exercise with moderate hypoglycemia symptoms. Measuring glucose (morning fasting 105-120 mg/dL, 2 hr post-meal 120-130 mg/dL). Chewing gum during exercise helps modulate glucose levels but still seems like there should be a better solution. Grain consumption 1-3/week. Limited sugar intake. Water and coffee w/heavy cream primary liquid consumption. Adrenal labs (normal DHEA, high normal cortisol). Worried Keto diet may further exacerbate during exercise. Any insight is greatly appreciated.

 

  1. (31:46) Adaptogens and Gut Microbiome adaption
    Eric says:

Digging the return of your podcast and the new format!  I have a couple of question submissions….

  • We interviewed folks live for the Meatcast at Expo West, and the most consistent “trend” everyone noted from the show was “adaptogens” – what are your thoughts on adaptogens?  Flash in the pan fad or the unicorn cure to cancer?  Surely it can’t be anything in between
  • Does our gut microbiome have the ability to adapt/evolve as we age, or is it “locked in” at a certain age?  We hear often that our exposure to good bacteria as a child impacts our autoimmunity later in life.  Whats so critical about those childhood years?  Is it simply our ability to adapt declining as we age?

 

  1. (38:53) Good workout regimen for novice?
    Joe says:
    Hi Robb & Nicki,Can you recommend a good resource for a workout regimen? Right now I do weight training circuits Monday, Wednesday, Friday. Cardio Tuesday and Thursday, usually one cardio session is an interval (3x 30 second all-out exertion on an elliptical and the rest of the 20 minutes at moderate pace). I do a circuit for 6 weeks, then just do cardio for a week then start a different circuit for the next 6 weeks. Etc.I’m currently doing alternate daily fasting on my circuit days. Good sleep, good energy. I’m just wondering about new/more efficient ways to mix up my workouts as I’m still following what I did circa the early 2000s. Thanks,
    Joe

 

I forgot to include a link to the Specialty Health blood work panel I mentioned in the show. Here ya go! 

 

Twitter: @RobbWolf
Instagram: @dasRobbWolf
Facebook: @RobbWolfOnline

 

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Episode 392 – RD Dikeman – Type 1 Diabetes Management


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This week on the podcast we have guest RD Dikeman. RD is Theoretical Physicist, Research Scientist, and father of a Type 1 Diabetic son.

Show Notes:
00:00 – Pre-Intro/Summary
3:49 – Robb and RD’s experiences with giving T1D information
6:38 – RD’s background and experience with T1D son
10:48 – Using Dr. Bernstein’s book and protocol
17:31 – Double diabetes (type 1 and 2 at the same time)
21:46 – Getting off the standard model of care
22:44 – Diabetes diet for the whole family, parents set the example
25:52 – Physicians and Dietitians telling dangerous myths to T1D parents
29:05 – Managing hypoglycemia
31:17 – How the Bernstein model looks
35:16 – Hypoglycemia and target blood sugar
38:40 – Robb’s blood sugar response and ketone levels
41:20 – High fat meals
43:24 – Chronically high blood sugars and Dr. Bernstein’s history
49:39 – What blood sugars should be in humans
51:31 – Ketogains and Fighting the nonsense in the low carb world
55:02 – Exercise and insulin sensitivity
57:39 – Using solid basics
59:40 – Hyperpalatability and fat bombs
1:00:53 – Reducing weight and fat to improve insulin resistance
1:03:52 – Where to find RD

RD’s video on Diet Doctor: https://www.dietdoctor.com/rd-dikeman-people-type-1-diabetes-avoid-disastrous-high-carb-diet

Diabetes University videos: https://www.youtube.com/channel/UCuJ11OJynsvHMsN48LG18Ag

Dr. Bernstein’s site: http://www.diabetes-book.com/

Book: Dr. Bernstein’s Diabetes Solution

RD’s son

RD’s son’s average glucose.

 

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Episode 391 – Tim Larkin – When Violence Is The Answer


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This week on Episode 391 of the podcast we have guest Tim Larkin. Tim is a defensive tactics and hand-to-hand combatives expert, and author of When Violence is the Answer. As a former military intelligence officer, he was part of a beta group that redesigned how Special Operations personnel trained for close combat. He has a 25 year career where he has trained over 10,000 people in 52 countries in how to deal with imminent violence, including working with groups like the Navy SEALS teams, SEAL Team 6, US Army Special Forces, FBI Rescue Team, and many more.

Show Notes:
00:00 – Pre-Intro/Summary
4:02 – Violence is a tool
8:08 – Battling the stigma of violence
15:02 – Teaching children about violence, and the difference of training males and females
18:45 – Antisocial aggression vs asocial violence
22:53 – Legal aspect of self defense, only responding when necessary, and avoidance
23:50 – Tim’s goal with training and informing people
26:40 – Violence has no demographic
29:15 – Training kids
35:32 – Pedophile danger
38:02 – Not sugar coating violence
40:07 – Self Protection is like CPR
41:24 – Competition and combat sports vs Destruction
43:18 – Looking at sports injury data for vulnerabilities
45:35 – Taking advantage of automatic body response to injury
46:50 – Is there efficacy of having previous martial arts training
49:07 – Alphas, the currency of violence, and the Aryan Brotherhood
53:11 – Getting effective first
56:56 – Edged weapons, firearms, and tools
59:21 – Slow deliberate training and deep practice
1:07:00 – How Robb and Tim were introduced, and Robb’s atlatl kill
1:08:15 – Where to find Tim’s work, and 10 week video course with book

Website: http://whenviolenceistheanswer.com/
Instagram: timlarkintft
Facebook: Tim Larkin
Book: When Violence is the Answer

 

Keto Masterclass

The keto diet is one of the most effective ways to shed fat and improve your health. Keto Masterclass helps you start keto right, step-by-step, so that you can be successful long-term.

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Wired-to-Eat-RenderDon’t forget, Wired to Eat is now available!

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Episode 98: The Supplement

On today’s show, we discuss the latest research on supplements; the McDonald’s Diet; losing weight with avocados; evidence based medicine; Michael Pollan’s thoughts on the Paleo Diet; happiness; and what’s wrong with dieting. Also, a few trailers for some potential entertainment choices.

Links for this episode:

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Episode 390 – Peter Jaworski – Markets


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This week on Episode 390 of The Paleo Solution Podcast we have Prof. Peter Jaworski. Prof. Jaworski is an Assistant Teaching Professor teaching business ethics. He was a Visiting Research Professor at Brown University, a Visiting Assistant Professor at the College of Wooster, and an Instructor at Bowling Green State University. He is also author of the book Markets without Limits: Moral Virtues and Commercial Interests.

Download a Transcript of this episode here (PDF)

Show Notes:

00:00 – Pre-Intro/Summary
4:04 – Intro, Markets
7:30 – Morality and disgust
9:30 – Medicine and health care
11:55 – Why is it so hard to have a conversation about health care, markets, and morality?
13:30 – Rise in cost in certain sectors
16:25 – Decentralized market experiments
17:50 – Telemedicine and medical tourism
19:13 – Medical product market across borders, and payment for blood plasma
25:28 – Markets don’t affect wrong or right
29:00 – Market outcomes affecting morality
30:05 – Anti-market attitudes, evolution, and collectivism
34:45 – Dunbar’s Number
37:40 – Where you can find Peter and his book

Website: marketswithoutlimits.com

Book: Markets without Limits: Moral Virtues and Commercial Interests

Keto Masterclass

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Wired-to-Eat-RenderDon’t forget, Wired to Eat is now available!

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Episode 99: Sugar vs. Fat

On today’s show, we tackle the recent BBC Horizon special called Sugar vs. Fat; also Subway’s bread controversy; there’s reason for concern regarding Vitamin C & E supplements as they relate to endurance training; the latest research on added sugar and heart disease; the government’s sugar guideline board’s ties to the food industry; and heart healthy sugar snacks. Also, we talk about False Dilemmas in the Moment of Paleo and we hear a conversation about Evidence Based Medicine in the After the Bell segment.

Links for this episode:

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Episode 387 – Q&A with Robb and Nicki


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Hey Folks!

We’re back with another Q&A episode (yes, we’re going to be doing these regularly)!

If you have a question for a future episode, submit them here https://robbwolf.com/contact/submit-a-question-for-the-podcast/

1. (3:00) Low Carb and Low Testosterone

Steve says:
Hey Robb and Nicki!

Any ideas as to why when I switched to low carb, my SHBG shot up, and, of course, my Free Testosterone went down…not good! I heard a podcast between Asprey and D’Agostino a while back and Dave mentioned that he was seeing that in a small percentage of clients, but did not know why? Hence…any thoughts you can provide would be helpful.

Stay the course…!!!
Steve

2. (5:30) Can visceral fat go away without procedures?

Annie says:

Hey Robb-
Thanks for looking over my question.
I am a 51 yr old woman- 27 years with Hashi’s and I was just diagnosed with Reactive Hypoglycemia.
(Additional Back story- I’ve recently come through a 3 yr ordeal with adrenal fatigue and whacked out thyroid)
In a recent Dexa scan, it showed that I have a layer of visceral fat (and a much higher general body fat % than I expected) which prompted my Endo/Functional Med doc to advise me to start taking Metformin (I cried- I feel like I lost ) .
The scan results explain why I can feel the solidity of my ab muscles , but still have a section in my lower belly that is distended from under my ab muscles and not the same quasi-flatness of my upper abs.
Even though I eat Low Carb/ Keto and do HIIT/Crossfit/Lifting 3-4 hours a week , I cannot seem to get the fat from this area to reduce or disappear.
Will these combined strategies( low carb, exercise and metformin) shrink fat cells or make the fat go away? Or am I doomed to this to be my new, undesirable situation? It’s not simply about vanity, its actually more about how I feel in a body that is not the one I’ve known and had to work with throughout the majority of my life. I’ve always been a mesomorph/athlete and usually around 20-22% body fat naturally (now I’m measured at 32%).

My question is it possible for that visceral belly fat to go away or get smaller through my current course of action? Or is that only possible through outside tools and resources like cool sculpting? I realize that sounds pretty vain, but again, it’s a big change for my body and I am not loving it at all.

Thanks Robb-

Annie

3. (14:01) Keto diet and raised triglycerides

Conor says:

Hi Robb,

Huge fan of everything you do! I know you are super busy, but when you get a chance could you expand on keto and triglycerides? I am a 24-year-old male, 5’10 180 and about 15% body fat, very committed to weightlifting, yoga, nutrition, and fitness in general. I just got back a blood test and I had a raised triglycerides levels, about 220. I was wondering if I can do anything to lower this or if this is even bad. Anything will help, and I will be looking forward to your response.

Excited about your upcoming content and everything you do!

Kind Regards,

Conor

4. (17:51) Fasting
Nate says :
How do you know when adding in fasting is appropriate? For those who have most things dialed in (sleep, appropriate exercise, etc.). Also, is doing a calorie deficit similar to the 5:2 diet (as opposed to a normal daily deficit) advisable?

Paper link: Caloric restriction does not enhance longevity in all species and is unlikely to do so in humans

5. (23:11) Women and Keto
Holly says:
Hi Robb,
I hear a lot of people talk about IF may be stressful for a woman’s hormones, potentially causing mood deregulation and/or hair loss. I occasionally eat more carbs to address this, although I’m not sure if I have to if I’m feeling fine. Is there any benefit to scheduled/regular increase in carbs for women, and how much are we talking about? What are the circumstances of IF being contraindicated?

There’s lots of flys in here Tony reference:
If you are ever depressed, this will fix it: https://youtu.be/WDQQfBrSUs0?t=2m13s (NSFW language warning)

6. (27:53) Fasting (answered with next question together in one)
Madison says:
Hello!

What is allowed during a period of fasting? Clear broth, coffee, lemon water, and tea, just water, or some combination?

Thank you!

7. (27:53) Intermittent fasting and coffee with coconut oil/milk (answered along with previous question)

Caroline says:
I’m trying to find a definitive answer as to whether having a coffee in the morning with 1 tbsp coconut oil and 2-3 tbsp coconut milk is a good thing or a bad thing whilst doing IF and trying to lose weight (16:8 or 24 hours). I usually have one around 7am and another one around 10am.  I skip breakfast and eat around 1.30pm.

Does it take me out of fasting mode and, if so, how quickly will I go back into fasting mode assuming I don’t eat anything?  Blood ketone tests show that my ketones increase by quite a lot after drinking coffee this way but is it having a negative impact on weight loss because my body is burning the fat in the coconut oil/milk rather than in my body?

There are many conflicting reports and opinions (most mainly about BPC) and I can’t find a definitive answer.

I found this site today which is the first one I’ve seen explained this way.

http://www.theiflife.com/2-meal-coconut-oil-coffee/

What’s your take on it?

My main goal is improved health (as measured by improved sleep and improved cognition) which I’m hoping will translate into weight loss of around another 12kg’s (lost 5kg’s through keto since mid January ’18).

Thanks!

 

Twitter: @RobbWolf
Instagram: @dasRobbWolf
Facebook: @RobbWolfOnline

 

Keto Masterclass

The keto diet is one of the most effective ways to shed fat and improve your health. Keto Masterclass helps you start keto right, step-by-step, so that you can be successful long-term.

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Wired-to-Eat-RenderDon’t forget, Wired to Eat is now available!

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